Author

M. Pein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Insua-Rodriguez· 3 shared J. Meier· 2 shared T. Hongu· 2 shared T. Oskarsson· 2 shared A. Descot· 1 shared A. Markaryan· 1 shared A. Riedel· 1 shared A. Schneeweiss· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

J. Insua-Rodriguez

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3 papers

Recent·Most cited

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

K. Nee, D. Ma, Q. H. Nguyen, N. Pervolarakis, J. Insua-Rodriguez, M. Pein, Y. Gong, G. Hernandez, H. Alshetaiwi, J. Williams, M. Rauf, K. R. Dave, K. Boyapati, C. Calderon, A. Markaryan, , K. Kessenbrock

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

bioRxiv · Oct 20, 2021 · PreprintCancer Biology

Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

T. Hongu, M. Pein, J. Insua-Rodriguez, J. Meier, K. Decker, A. Descot, A. Riedel, T. Oskarsson

The paper identifies four secreted factors from metastasis-associated endothelial cells that promote breast cancer metastasis by enhancing cancer cell stemness and survival, with perivascular macrophages mediating this effect via the TNC-TLR4 axis.

bioRxiv · Mar 30, 2021Cancer Biology

CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization

M. Pein, J. Insua-Rodriguez, J. Meier, T. Hongu, L. Wiedmann, M. A. G. Essers, H.-P. Sinn, S. Spaich, M. Sutterlin, A. Schneeweiss, A. Trumpp, T. Oskarsson

This study identifies CXCR3-expressing breast cancer cells that induce fibroblast production of CXCL9/10 via IL-1 and JNK signaling, promoting metastatic colonization in the lungs.

bioRxiv · Feb 11, 2019Cancer Biology