Author

K. Kessenbrock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2 Immunology· 1

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Research Focus:cell type annotation· 6 Organism:human· 6 Assay:scRNA-seq· 5 Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:cell-cell communication· 3 Approach:deep learning· 3 Research Focus:differential expression· 3

Frequent Co-Authors

N. Pervolarakis· 5 shared K. Nee· 4 shared Q. Nguyen· 4 shared D. Ma· 3 shared H. Alshetaiwi· 3 shared C. C. Hughes· 2 shared D. A. Lawson· 2 shared G. Hernandez· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersCancer Biology

N. Pervolarakis

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

S. J. Hachey, C. J. Hatch, D. Gaebler, A. Mocherla, K. Nee, K. Kessenbrock, C. C. Hughes

The paper uses a vascularized micro-tumor model to identify therapeutic targets in TNBC stromal interactions, showing efficacy of Tie2 and Her3/Akt inhibition.

bioRxiv · Sep 6, 2023Cancer Biology

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

G. COULIS, D. Jaime, C. Guerrero-Juarez, J. Kastenschmidt, P. Farahat, Q. Nguyen, N. Pervolarakis, K. McLinden, L. Thurlow, S. Movahedi, B. Hughes, J. Duarte, A. Sorn, E. Montoya, I. Mozaffar, , A. Villalta

bioRxiv · Apr 18, 2023Immunology

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

K. Nee, D. Ma, Q. H. Nguyen, N. Pervolarakis, J. Insua-Rodriguez, M. Pein, Y. Gong, G. Hernandez, H. Alshetaiwi, J. Williams, M. Rauf, K. R. Dave, K. Boyapati, C. Calderon, A. Markaryan, , K. Kessenbrock

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

bioRxiv · Oct 20, 2021 · PreprintCancer Biology

Fine-tuning of Epithelial EGFR signals Supports Coordinated Mammary Gland Development

A. Samocha, H. Doh, V. Sitarama, Q. Nguyen, O. Gbenedio, J. Rudolf, W. Eckalbar, A. Barczak, Y. Miao, C. Garcia, D. Lawson, Z. Werb, K. Kessenbrock, P. Depeille, J. Roose

This study shows that Rasgrp1 fine-tunes EGFR signals in mammary epithelial cells to regulate development during puberty, with in vitro and in vivo effects on proliferation, branching, and cellularity.

bioRxiv · Sep 10, 2020 · PreprintCell Biology

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

D. Ma, G. A. Hernandez, A. E. Y. T. Lefebvre, H. Alshetaiwi, K. Blake, K. R. Dave, M. Rauf, J. W. Williams, R. T. Davis, K. T. Evans, M. Y. G. Masoud, R. Lee, R. A. Edwards, M. A. Digman, K. Kessenbrock, D. A. Lawson

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

bioRxiv · Jun 25, 2020 · PreprintCancer Biology

An In Vitro Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates In Vivo Drug Responses

S. J. Hachey, S. Movsesyan, Q. H. Nguyen, G. Burton-Sojo, A. Tankazyan, J. Wu, T. Hoang, M. M. Hatch, D. Zhao, E. Celaya, S. Gomez, G. T. Chen, R. T. Davis, K. Nee, N. Pervolarakis, , C. C. Hughes

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

bioRxiv · Mar 3, 2020Cancer Biology

Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity

N. Pervolarakis, Q. Nguyen, G. Gutierrez, P. Sun, D. Jhutty, G. X. Zheng, C. M. Nemec, X. Dai, K. Watanabe, K. Kessenbrock

The paper integrates single-cell transcriptomics and chromatin accessibility analysis to identify novel regulatory elements in mouse mammary epithelial cells and their differentiation states.

bioRxiv · Aug 20, 2019Cell Biology

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

H. Alshetaiwi, N. Pervolarakis, L. L. McIntyre, D. Ma, Q. Nguyen, J. A. Rath, K. Nee, G. Hernandez, K. Evans, L. Torosian, A. Silva, C. Walsh, K. Kessenbrock

This study identifies unique molecular features of MDSCs using single-cell transcriptomics, revealing a distinct maturation trajectory and novel surface markers for their detection.

bioRxiv · Jul 15, 2019Cancer Biology