Author

M. Petrascheck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:graph neural network· 1

Frequent Co-Authors

K. J. Clay· 2 shared A. L. Chen· 1 shared B. F. Cravatt· 1 shared B. K. Kennedy· 1 shared D. Miller· 1 shared E. R. Valentine· 1 shared G. M. Solis· 1 shared J. R. Williamson· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPharmacology & Toxicology

K. J. Clay

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Author profile →

4 papers

Recent·Most cited

Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology

K. Avchaciov, K. J. Clay, O. Burmistrova, M. Petrascheck, P. O. Fedichev

The paper uses graph neural networks to predict polypharmacological compounds that extend lifespan in C. elegans, finding 70% of selected compounds significantly increase lifespan.

bioRxiv · Jun 23, 2024 · PreprintPharmacology & Toxicology

Proteostasis is differentially modulated by inhibition of translation initiation or elongation

K. J. Clay, Y. Yang, M. Petrascheck

This study shows that inhibiting translation initiation or elongation in C. elegans activates distinct proteostatic mechanisms, with different effects on lifespan and stress resistance.

bioRxiv · Jan 23, 2022Biochemistry

Translation Attenuation by Minocycline Increases Lifespan and Improves Proteostasis in Old Post-Stress-Responsive Organisms

G. M. Solis, R. Kardakaris, E. R. Valentine, L. Bar-Peled, A. L. Chen, M. M. Blewett, M. A. McCormick, J. R. Williamson, B. K. Kennedy, B. F. Cravatt, M. Petrascheck

This study shows minocycline extends lifespan and reduces protein aggregation in old C. elegans by inhibiting translation of highly expressed mRNAs, improving proteostasis without activating stress pathways.

bioRxiv · Jul 19, 2018 · PreprintPhysiology

Computational Analysis of Lifespan Experiment Reproducibility

M. Petrascheck, D. Miller

This study assesses the reproducibility of C. elegans lifespan experiments and finds that small effects are rarely detected due to low statistical power, suggesting the need for larger sample sizes.

bioRxiv · Feb 9, 2017Physiology