M. R. Ahmadian

This study identifies SIRT4 as a specific interactor of C-RAF kinase, showing it suppresses MAPK signaling by stabilizing the inactive form of C-RAF.

This study shows CoCl2 induces SIRT4 degradation through proteasomal polyubiquitination at K78 and K299, and via autophagy/mitophagy.

This study characterizes the Arabidopsis thaliana GTPase TTN5, revealing its rapid nucleotide exchange, non-classical GTPase activity, and dynamic membrane association in endomembrane transport.

This study identifies a novel LZTR1 variant causing cardiac hypertrophy by altering protein polymerization and ubiquitin ligase function, showing genetic correction can rescue the phenotype.

This study uses patient-derived iPSCs to model RAF1-associated Noonan syndrome and identifies sarcomere structural abnormalities linked to cardiac dysfunction.

This study identifies SIRT4 as a centrosomal and microtubule-associated protein that delays mitotic progression and reduces cell proliferation.