Author

L. Cyganek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Organism:mouse· 2 Research Focus:synaptic & neural circuits· 2

Frequent Co-Authors

A. V. Busley· 2 shared I. C. Cirstea· 2 shared M. R. Ahmadian· 2 shared A. Alekseev· 1 shared A. Borchardt· 1 shared A. Garrido-Charles· 1 shared A. Hahn· 1 shared A. Huet· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

A. V. Busley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Efficient and sustained optogenetic control of sensory and cardiac systems

A. Alekseev, V. Hunniford, M. Zerche, M. Jeschke, F. El May, A. Vavakou, D. Siegenthaler, M. A. Hueser, S. M. Kiehn, A. Garrido-Charles, A. Meyer, A. Rambousky, T. Alvanos, I. Witzke, K. D. Rojas-Garcia, , T. Moser

This paper introduces ChReef, an improved optogenetic tool with enhanced performance in sensory and cardiac systems, demonstrating its effectiveness in restoring visual and auditory function.

bioRxiv · Nov 17, 2023Biophysics

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

A. V. Busley, O. Gutierrez-Gutierrez, E. Hammer, F. Koitka, A. Mirzaiebadizi, M. Steinegger, C. Pape, L. Boehmer, H. Schroeder, M. Kleinsorge, M. Engler, I. C. Cirstea, L. Gremer, D. Willbold, J. Altmueller, , L. Cyganek

This study identifies a novel LZTR1 variant causing cardiac hypertrophy by altering protein polymerization and ubiquitin ligase function, showing genetic correction can rescue the phenotype.

bioRxiv · Jan 10, 2023Cell Biology

Alteration of myocardial structure and function in RAF1associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs

S. Nakhaei-Rad, F. Bazgir, J. Dahlmann, A. V. Busley, M. Buchholzer, F. Haghighi, A. Schaenzer, A. Hahn, S. Koetter, D. Schanze, R. Anand, F. Funk, A. Borchardt, A. V. Kronenbitter, J. Scheller, , M. R. Ahmadian

This study uses patient-derived iPSCs to model RAF1-associated Noonan syndrome and identifies sarcomere structural abnormalities linked to cardiac dysfunction.

bioRxiv · Jan 22, 2022 · PreprintCell Biology

Effects of Hydroxychloroquine and Azithromycin on iPSC-derived Cardiomyocytes: Considerations for the Treatment of COVID-19 Patients

W. Li, X. Luo, M. S. Poetsch, R. Oertel, K. Nichani, M. Schneider, A. Strano, M. Hasse, R. P. Steiner, L. Cyganek, K. Hettwer, S. Uhlig, K. Simon, K. Guan, M. Schubert

This study investigates the effects of HCQ and AZM on iPSC-derived cardiomyocytes, finding that their combination significantly increases cardiotoxicity and electrophysiological dysfunction.

bioRxiv · Aug 19, 2021 · PreprintPharmacology & Toxicology

Local translation in synaptic mitochondria influences synaptic transmission

R. Yousefi, E. F. Fornasiero, L. Cyganek, S. Jakobs, S. O. Rizzoli, P. Rehling, D. Pacheu Grau

The paper uses an imaging approach to study mitochondrial translation in neurons, finding it occurs in dendrites and axons, correlates with synaptic activity, and affects synaptic function.

bioRxiv · Jul 22, 2020 · PreprintBiochemistry