Author

M. R. Molenaar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:metabolomics· 2

Frequent Co-Authors

J. B. Helms· 2 shared T. A. Wassenaar· 2 shared A. B. Vaandrager· 1 shared A. Chorlay· 1 shared A. Dugourd· 1 shared A. Eisenbarth· 1 shared A. Jeucken· 1 shared A. Mansouri· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

J. B. Helms

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Author profile →

4 papers

Recent·Most cited

Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer cells

E. Buglakova, M. Ekelöf, M. Schwaiger-Haber, L. Schlicker, M. R. Molenaar, S. Mohammed, L. Stuart, A. Eisenbarth, V. Hilsenstein, G. Patti, A. Schulze, M. Snaebjornsson, T. Alexandrov

This paper introduces 13C-SpaceM, a method for spatial single-cell isotope tracing of de novo fatty acid synthesis in cancer cells, revealing metabolic heterogeneity in liver and glioma tissues.

bioRxiv · Aug 18, 2023 · PreprintBiochemistry

Increasing triacylglycerol formation and lipid storage by unsaturated lipids protects renal proximal tubules in diabetes

A. Perez-Marti, S. Ramakrishnan, J. Li, A. Dugourd, M. R. Molenaar, L. R. De La Motte, K. Grand, A. Mansouri, M. Parisot, S. S. Lienkamp, J. Saez-Rodriguez, M. Simons

This study shows that unsaturated lipids reduce renal damage in diabetes by increasing lipid storage and protecting against ER stress in proximal tubular cells.

bioRxiv · Sep 7, 2021Cell Biology

Lecithin:Retinol Acyl Transferase (LRAT) inducesthe formation of lipid droplets

M. R. Molenaar, T. A. Wassenaar, K. K. Yadav, A. Toulmay, M. C. Mari, L. Caillon, A. Chorlay, M. W. Haaker, R. W. Wubbolts, M. Houweling, A. B. Vaandrager, F. Reggiori, A. R. Thiam, W. A. Prinz, J. B. Helms

This study shows that LRAT produces retinyl esters in yeast, leading to lipid droplet formation, which is morphologically similar to wild-type droplets and confirmed by in silico and in vitro experiments.

bioRxiv · Aug 14, 2019Biochemistry

LION/web: a web-based ontology enrichment tool for lipidomic data analysis

M. R. Molenaar, A. Jeucken, T. A. Wassenaar, C. H. A. van de Lest, J. F. Brouwers, J. B. Helms

LION/web is a web-based tool that uses a lipid ontology to identify lipid-associated terms in lipidomic data, validated using macrophage and CHO cell datasets.

bioRxiv · Oct 7, 2018Biochemistry