Author

A. R. Thiam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell signaling & trafficking· 8 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

M. Omrane· 3 shared D. Ajjaji· 2 shared M. Carpentier· 2 shared P. Campomanes· 2 shared S. Vanni· 2 shared V. Zoni· 2 shared A. B. Vaandrager· 1 shared A. Bacle· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

M. Omrane

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Perilipin membrane-integration determines Lipid Droplet heterogeneity in differentiating adipocytes

M. Majchrzak, O. Stojanovic, D. Ajjaji, K. Ben M'barek, M. Omrane, A. R. THIAM, R. W. Klemm

This paper investigates how perilipin membrane integration determines lipid droplet heterogeneity in differentiating adipocytes by showing that an unconventional integral membrane segment directs PLIN1 to the ER and influences LD-class specificity.

Cell Reports · Apr 1, 2024Peer-reviewedCell Biology

The α/β hydrolase domain-containing protein 1 (ABHD1) acts as a lysolipid lipase and is involved in lipid droplet formation

I. Torres Romero, B. Legeret, M. Huleux, D. Sorigue, A. Damm, S. Cuine, F. Veillet, C. Blot, S. Brugiere, Y. Coute, M. G. Garneau, H. Kotapati, Y. Xin, J. Xu, P. D. Bates, , Y. Li-Beisson

This paper identifies ABHD1 as a lysolipid lipase involved in lipid droplet formation through enzymatic and structural actions on the LD surface in Chlamydomonas.

bioRxiv · Dec 17, 2023Biochemistry

ATG2A-mediated bridge-like lipid transport regulates lipid droplet accumulation

J. L. Korfhage, N. Wan, H. Elhan, L. Kauffman, M. J. Pineda, D. M. Fuller, A. R. Thiam, K. Reinisch, T. Melia

This study shows ATG2A uses bridge-like lipid transport to regulate lipid droplet accumulation by efficiently moving phospholipids between membranes.

bioRxiv · Aug 14, 2023Cell Biology

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

Y.-M. Choi, D. Ajjaji, K. D. Fleming, P. P. Borbat, M. L. Jenkins, B. E. Moeller, S. Fernando, S. R. Bhatia, J. H. Freed, J. E. Burke, A. R. Thiam, M. V. Airola

The paper investigates how lipid composition, specifically phosphatidic acid and diacylglycerol, affects PLIN3 recruitment to membranes and LDs, revealing structural changes in the PAT domain.

bioRxiv · Nov 17, 2022Biochemistry

Triglyceride lipolysis driven by glucose restriction triggers liquid-crystalline phase transitions and proteome remodeling of lipid droplets

S. Rogers, L. Gui, A. Kovalenko, V. Zoni, M. Carpentier, K. Ramji, K. Ben Mbarek, A. Bacle, P. Fuchs, P. Campomanes, E. Reetz, N. O. Speer, E. Reynolds, A. R. Thiam, S. Vanni, , W. M. Henne

The paper shows glucose restriction induces liquid-crystalline phase transitions in lipid droplets by promoting TG lipolysis, which alters lipid composition and remodels the proteome.

bioRxiv · Apr 15, 2022Cell Biology

MOSPD2 a new endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis

M. ZOUIOUICH, T. DI MATTIA, A. MARTINET, J. EICHLER, C. WENDLING, N. TOMISHIGE, E. GRANDGIRARD, N. FUGGETTA, C. RAMAIN, G. MIZZON, C. Dumesnil, M. CARPENTIER, B. REINA-SAN-MARTIN, C. MATHELIN, Y. Schwab, , F. ALPY

This study identifies MOSPD2 as an ER-lipid droplet tether that regulates LD homeostasis through its CRAL-TRIO domain.

bioRxiv · Feb 11, 2022Cell Biology

ORP5 AND ORP8 ORCHESTRATE LIPID DROPLET BIOGENESIS AND MAINTENANCE AT ER-MITOCHONDRIA CONTACT SITES

V. Guyard, V. F. Monteiro-Cardoso, M. Omrane, C. Sauvanet, A. Houcine, C. Boulogne, K. B. MBarek, N. Vitale, O. Facklaris, N. El Khallouki, A. R. Thiam, F. Giordano

This study identifies ORP5 and ORP8 as regulators of lipid droplet biogenesis at ER-mitochondria contact sites by controlling seipin recruitment and phosphatidic acid enrichment.

bioRxiv · Nov 11, 2021Cell Biology

Lipid droplet biogenesis is driven by a liquid-liquid phase separation.

V. Zoni, R. Khaddaj, P. Campomanes, A. R. Thiam, R. Schneiter, S. Vanni

The paper shows that lipid droplet formation results from liquid-liquid phase separation, influenced by ER membrane properties and lipid composition.

bioRxiv · Jan 23, 2020Cell Biology

Lecithin:Retinol Acyl Transferase (LRAT) inducesthe formation of lipid droplets

M. R. Molenaar, T. A. Wassenaar, K. K. Yadav, A. Toulmay, M. C. Mari, L. Caillon, A. Chorlay, M. W. Haaker, R. W. Wubbolts, M. Houweling, A. B. Vaandrager, F. Reggiori, A. R. Thiam, W. A. Prinz, J. B. Helms

This study shows that LRAT produces retinyl esters in yeast, leading to lipid droplet formation, which is morphologically similar to wild-type droplets and confirmed by in silico and in vitro experiments.

bioRxiv · Aug 14, 2019Biochemistry

Two polybasic domains of septin9 control septin filaments assembly and Golgi integrity

M. Omrane, A. S. Camara, C. Taveneau, N. Benzoubir, T. Tubiana, J. Yu, R. Guerois, D. Samuel, B. Goud, C. Pous, S. Bressanelli, R. C. Garratt, A. R. Thiam, A. Gassama-Diagne

This study identifies two polybasic domains in septin 9 that mediate interaction with phosphoinositides and are critical for septin filament assembly and Golgi integrity.

bioRxiv · Jan 31, 2019 · PreprintCell Biology