M. Samuel

Nucleus- and plastid-targeted annexin 5 promotes reproductive development in Arabidopsis and is essential for pollen and embryo formation

This study shows that ANN5 promotes reproductive development in Arabidopsis by regulating pollen and embryo formation through its localization in nuclei, plastids, and interactions with RABE1b.

Somatic Mutations Predict Acute Myeloid Leukemia Years Before Diagnosis

This study identifies somatic mutations in peripheral blood that predict acute myeloid leukemia (AML) years before diagnosis, with TP53 mutations showing the strongest association and earliest onset.

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.