P. Desai

Genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumor

This study compares genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumors in SCLC patients, finding cfDNA reflects tumor mutations, identifies resistance mechanisms, and tracks tumor evolution.

Ipsilateral or contralateral boosting of mice with mRNA vaccines confers equivalent immunity and protection against a SARS-CoV-2 Omicron strain

This study shows that boosting mice with mRNA vaccines in the ipsilateral or contralateral arm leads to equivalent immune responses and protection against SARS-CoV-2 Omicron.

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2

This study shows that intestinal helminth infection reduces T cell responses to an mRNA SARS-CoV-2 vaccine and weakens protection against Omicron but not the ancestral strain.

ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer

This study shows that combining ATR inhibition with lurbinectedin improves efficacy in SCLC, particularly in MYC-driven non-neuroendocrine tumors.

A bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 infection and disease in mice and hamsters

This paper shows a bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 in mice and hamsters through mucosal immunity, despite poor serum neutralizing antibody responses.

A NOVEL METHOD FOR BLOOD DETECTION USING FLUORESCENT DYE

This paper develops a new fluorescent dye method for blood detection that avoids toxicity and false positives, effectively detecting blood up to 20 days old without damaging DNA.

Fc-gamma receptor-dependent antibody effector functions are required for vaccine protection against infection by antigenic variants of SARS-CoV-2

This study shows that Fc-gamma receptor-dependent antibody effector functions are necessary for vaccine protection against antigenic variants of SARS-CoV-2, including Omicron.

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

Computational analysis reveals similarities and differences between SCLC subtypes

The paper analyzes SCLC subtypes using gene expression data to determine their similarities and differences, identifying co-expressed modules and classifying cell lines into clusters.

Topoisomerase VI is a chirally-selective, preferential DNA decatenase

This study shows that topoisomerase VI preferentially decatenates DNA crossings over relaxing supercoils by sensing specific DNA geometries.

Salmonella Enhances Osteogenic Differentiation in Adipose-Derived Mesenchymal Stem Cells

This study shows Salmonella affects osteogenic and chondrogenic differentiation in adipose-derived MSCs by altering gene expression and signaling pathways.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

Somatic Mutations Predict Acute Myeloid Leukemia Years Before Diagnosis

This study identifies somatic mutations in peripheral blood that predict acute myeloid leukemia (AML) years before diagnosis, with TP53 mutations showing the strongest association and earliest onset.