Author

M. Schlierf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:fluorescence / live-cell microscopy· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Hartmann· 4 shared G. Krainer· 3 shared N. Chamachi· 3 shared T. Ha· 2 shared A. Barth· 1 shared A. Kapanidis· 1 shared A. Sefer· 1 shared B. Ambrose· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

A. Hartmann

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6 papers

Recent·Most cited

The recombination efficiency of the bacterial integron depends on the mechanical stability of the synaptic complex

E. Vorobevskaia, C. Loot, D. Mazel, M. Schlierf

The paper investigates how the mechanical stability of the integron synaptic complex affects recombination efficiency in bacteria, finding a strong correlation between stability and efficiency.

bioRxiv · Apr 9, 2024 · PreprintBiophysics

Farewell to single-well: An automated single-molecule FRET platform for high-content, multiwell plate screening of biomolecular conformations and dynamics

A. Hartmann, K. Sreenivasa, M. Schenkel, N. Chamachi, P. Schake, G. Krainer, M. Schlierf

This paper introduces an automated multiwell plate platform for single-molecule FRET that enables high-content screening of biomolecular conformations and dynamics with improved accuracy and efficiency.

bioRxiv · Feb 28, 2023Biophysics

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

G. Agam, C. Gebhardt, M. Popara, R. Maechtel, J. Folz, B. Ambrose, N. Chamachi, S. Y. Chung, T. D. Craggs, M. de Boer, D. Grohmann, T. Ha, A. Hartmann, J. Hendrix, V. Hirschfeld, , T. Cordes

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

bioRxiv · Aug 3, 2022Biophysics

Chaperones Skp and SurA dynamically expand unfolded outer membrane protein X and synergistically disassemble oligomeric aggregates

N. Chamachi, A. Hartmann, M. Q. Ma, G. Krainer, M. Schlierf

This study investigates how chaperones Skp and SurA interact with unfolded OmpX, showing they expand the protein and synergistically disassemble aggregates through dynamic and thermodynamic processes.

bioRxiv · Feb 23, 2021 · PreprintBiophysics

Direct visualization of four diffusive LexA states controlling SOS response strength during antibiotic treatment

L. Schaerfen, M. Tisma, A. Hartmann, M. Schlierf

This study visualizes four diffusive LexA states in E. coli during antibiotic treatment, revealing their dynamics and role in SOS response regulation.

bioRxiv · Jul 14, 2020 · PreprintBiophysics

Hexameric helicase G40P unwinds DNA in single base pair steps

M. Schlierf, G. Wang, X. S. Chen, T. Ha

This study investigates DNA unwinding by the hexameric helicase G40P using single-molecule fluorescence, revealing single base pair unwinding and coordinated ATP hydrolysis.

bioRxiv · Oct 1, 2018Biophysics