R. Anand

Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

The paper shows MIC26 regulates metabolic pathways by modulating mitochondrial metabolite exchange, with its role reversing under hyperglycemia.

MIC13 and SLP2 seed the assembly of MIC60-subcomplex to facilitate crista junction formation

This study identifies SLP2 as an auxiliary MICOS subunit that interacts with MIC13 to seed MIC60 assembly and promote crista junction formation.

Identifying Selectivity Filters in Protein Biosensor for Ligand Screening

The paper identifies selectivity filters in MopR, a bacterial phenol biosensor, that screen ligands based on chemical features and size, revealing conserved mechanisms for ligand selection.

Live-cell super-resolution nanoscopy reveals modulation of cristae dynamics in bioenergetically compromised mitochondria

The paper uses live-cell nanoscopy to study cristae dynamics under various bioenergetic conditions and finds that cristae remodeling is independent of mitochondrial membrane potential but affected by ADP/ATP exchange.

Phenol Sensing in Nature Modulated via a Conformational Switch Governed by Dynamic Allostery

The paper shows that MopR, an NtrC protein, uses dynamic allostery to sense phenol, altering its conformation and ATPase activity, with implications for evolutionary conservation.

Alteration of myocardial structure and function in RAF1associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs

This study uses patient-derived iPSCs to model RAF1-associated Noonan syndrome and identifies sarcomere structural abnormalities linked to cardiac dysfunction.

Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methytransferases

This study determines the structure of 30S-KsgA and identifies factors guiding its specificity, enabling strategies to reverse methylation-mediated antibiotic resistance.

Interactive effects of microplastic pollution and heat stress on reef-building corals

This study examines how microplastic pollution and heat stress interact to affect reef-building corals, finding that heat stress is more severe than microplastic exposure.

Protease OMA1 Modulates Mitochondrial Bioenergetics and Ultrastructure through Dynamic Association with MICOS Complex

This study identifies OMA1's role in maintaining mitochondrial ultrastructure and bioenergetics through its interaction with the MICOS complex, showing its importance in cellular stress responses and apoptosis.

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

The paper uses single-molecule imaging to show how BRC-2 and RFS-1/RIP-1 mediate RAD-51 filament nucleation and growth during homologous recombination.

Regulation of the MLH1-MLH3 endonuclease in meiosis

This paper identifies the molecular mechanism by which the MLH1-MLH3 nuclease is activated in meiosis, showing its interaction with MutSγ, EXO1, RFC, and PCNA to process recombination intermediates.

CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection

This study shows phosphorylated CtIP enhances DNA2's motor activity, promoting RPA-coated ssDNA degradation and linking short and long-range DNA resection.

Cristae undergo continuous cycles of fusion and fission in a MICOS-dependent manner

The paper uses live-cell imaging to show mitochondrial cristae undergo continuous fusion and fission, dependent on MIC13, with dynamics similar to crista junctions.