The SARS-CoV-2 accessory factor ORF7a downregulates MHC class I surface expression
S. Zheng, H. de Buhr, P. Praest, A. Evers, I. Brak Boer, M. van Grinsven, Y. Longo, L. de Vries, W. Nijenhuis, L. C. Kapitein, J. M. Beekman, M. Nijhuis, I. Drexler, E. J. Wiertz, R. J. Lebbink
This study identifies SARS-CoV-2 ORF7a as a viral factor that downregulates MHC class I surface expression, impairing antigen presentation and immune surveillance.
bioRxiv · May 29, 2022 · PreprintMicrobiology