Author

M. W. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:plant (other)· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

J. Lescar· 2 shared A. El Sahili· 1 shared A. P. Lane· 1 shared A. Pekosz· 1 shared B. Smith· 1 shared C. Caputo· 1 shared C. F. Brayton· 1 shared C. W. Liew· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

J. Lescar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Erythrocyte signalling is critical for Plasmodium falciparum invasion

J. J. M. Yong, X. Gao, P. Prakash, S. K. Lai, M. W. Chen, J. J. L. Neo, J. Lescar, H. Y. Li, P. R. Preiser

This study shows that Plasmodium falciparum merozoite invasion depends on host cAMP-Ca2+ signalling, with RH5-Basigin interaction triggering cAMP rise and Ca2+ influx.

bioRxiv · Jul 18, 2022 · PreprintMicrobiology

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

L. Jiang, T. Driedonks, M. Lowman, W. S. Jong, H. B. van den Berg van Saparoea, S. Dhakal, R. Zhou, C. Caputo, K. Littlefield, I. Sitaras, M. W. Chen, G. Lima, O. Gololobova, B. Smith, V. Mahairaki, , K. W. Witwer

bioRxiv · Jun 28, 2021Immunology

Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3 upon binding to protease inhibitors

W. W. Phoo, A. El Sahili, C. W. Liew, J. Lescar, S. Vasudevan, D. Luo, M. W. Chen

The paper reports crystal structures of DENV4 NS2B-NS3 constructs with and without protease inhibitors, showing how different linkers affect the enzyme's conformation and activity.

bioRxiv · Jan 27, 2020Biochemistry