Author

K. Littlefield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Pekosz· 3 shared J. L. Mankowski· 2 shared R. Zhou· 2 shared S. Dhakal· 2 shared S. L. Klein· 2 shared A. A. Tobian· 1 shared A. Braxton· 1 shared A. Casadevall· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

A. Pekosz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS-CoV-2-specific T cells associate with reduced lung function and inflammation in pulmonary post-acute sequalae of SARS-CoV-2

K. Littlefield, R. Watson, J. Schneider, C. Neff, E. Yamada, M. Zhang, T. Campbell, M. Falta, S. Jolley, A. Fontenot, B. Palmer

This study finds that elevated SARS-CoV-2-specific T cells in individuals with pulmonary PASC correlate with increased inflammation and reduced lung function.

bioRxiv · Feb 14, 2022Immunology

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

L. Jiang, T. Driedonks, M. Lowman, W. S. Jong, H. B. van den Berg van Saparoea, S. Dhakal, R. Zhou, C. Caputo, K. Littlefield, I. Sitaras, M. W. Chen, G. Lima, O. Gololobova, B. Smith, V. Mahairaki, , K. W. Witwer

bioRxiv · Jun 28, 2021Immunology

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

S. Dhakal, C. A. Ruiz-Bedoya, R. Zhou, P. Creisher, J. Villano, K. Littlefield, J. Castillo, P. Marinho, A. Jedlicka, A. Ordonez, N. Majewska, M. Betenbaugh, K. Flavahan, A. Mueller, M. Looney, , S. L. Klein

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

bioRxiv · Apr 2, 2021Microbiology

CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entireSARS-CoV-2 proteome and show kinetics of early differentiation

H. Kared, A. D. Redd, E. M. Bloch, T. S. Bonny, H. Sumatoh, F. Kairi, D. Carbajo, B. Abel, E. W. Newell, M. P. Bettinotti, S. E. Benner, E. U. Patel, K. Littlefield, O. Laeyendecker, S. Shoham, , T. C. Quinn

The paper identifies CD8+ T cell epitopes across the SARS-CoV-2 proteome in convalescent individuals and shows their differentiation kinetics and correlation with immune markers.

bioRxiv · Oct 8, 2020 · PreprintImmunology