Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection
Q. T. Phan, N. V. Solis, M. V. Cravener…·S. G. Filler
This study identifies a multi-receptor complex involving c-Met, E-cadherin, and EGFR that C. albicans uses to invade oral epithelial cells, with Hyr1 and Als3 facilitating this process and dual inhibition of c-Met and EGFR reducing virulence.