A. S. Ibrahim

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

This paper identifies brilacidin as a novel antifungal agent effective against Cryptococcus neoformans, showing it reduces fungal survival in macrophages and potentiates existing antifungals.

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection

This study identifies a multi-receptor complex involving c-Met, E-cadherin, and EGFR that C. albicans uses to invade oral epithelial cells, with Hyr1 and Als3 facilitating this process and dual inhibition of c-Met and EGFR reducing virulence.

CotH genes are necessary for normal spore formation and virulence in Mucor lusitanicus

This study identifies CotH genes in Mucor lusitanicus and shows their role in spore formation, virulence, and cell wall structure through CRISPR-Cas9 disruption and infection models.

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity

The paper identifies a bacterial endosymbiont in Rhizopus microsporus that enhances fungal virulence by suppressing amoeba predation and macrophage clearance.

GRP78 and Integrins Play Different Roles in Host Cell Invasion During Mucormycosis

This study identifies GRP78 and integrins as distinct host receptors for Rhizopus delemar invasion in nasal and alveolar epithelial cells, explaining differential mucormycosis susceptibility in DKA and hematologic malignancy patients.

Preserving Vascular Integrity Protects Mice Against Multidrug-Resistant Gram-Negative Bacterial Infection

This study shows that inhibiting ARF6 protects mice from MDR Gram-negative bacterial infections by preserving vascular integrity.

Tornadic shear stress induces a transient, calcineurin-dependent hyper-virulent phenotype in Mucorales molds

This study shows that tornadic shear stress induces a transient, calcineurin-dependent hyper-virulent phenotype in Mucorales molds, with potential therapeutic implications for trauma-related mucormycosis.

Monoclonal IgM antibodies raised against Candida albicans Hyr1 provide cross-kingdom protection against Gram negative bacteria

The paper shows monoclonal antibodies against Candida albicans Hyr1 protect against Gram-negative bacterial infections.

NDV-3A vaccination protects mice from Candida albicans biofilm infection

NDV-3A vaccine protects mice from Candida albicans biofilm infection by inducing antibodies that block adherence, invasion, and dispersal of the fungus.

The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection

This paper shows that the NDV-3A vaccine protects mice from lethal C. auris infections and enhances antifungal drug efficacy.

Alexidine dihydrochloride has broad spectrum activities against diverse fungal pathogens

This study identifies Alexidine dihydrochloride as a broad-spectrum antifungal drug effective against multiple fungal pathogens and preformed biofilms.

Human Als3p Antibodies are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis

The paper evaluates anti-Als3p antibodies as surrogate markers for NDV-3A vaccine efficacy against recurrent vulvovaginal candidiasis by comparing vaccinated individuals with and without recurrence.