N. V. Solis

Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypes

This study identifies ERG251 mutations that confer azole tolerance and pleiotropic effects on stress responses and filamentation in C. albicans.

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates biofilm formation and oral commensalism

This paper identifies a rare, dominant SNP in the Rob1 transcription factor of C. albicans strain SC5314 that enhances biofilm formation and filamentation, contributing to its distinct phenotypic traits.

Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection

This study identifies a multi-receptor complex involving c-Met, E-cadherin, and EGFR that C. albicans uses to invade oral epithelial cells, with Hyr1 and Als3 facilitating this process and dual inhibition of c-Met and EGFR reducing virulence.

Candida albicans oropharyngeal infection is an exception to iron-based nutritional immunity

This study compares C. albicans gene expression in oral and kidney infections, finding it is iron-replete in oral tissue but iron-starved in the kidney, suggesting exemption from iron-based nutritional immunity in oral infections.

Niclosamide loaded Eudragit EPO nanoparticles show enhanced Candida biofilm penetration, trigger biofilm detachment and protect from mucosal candidiasis

This study identifies Niclosamide as a drug that disrupts Candida biofilms and develops nanoparticles to enhance its efficacy against drug-resistant strains.

IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis

This study identifies IL-23 signaling as a protective mechanism against ferroptosis-driven renal immunopathology during disseminated candidiasis.

Identification of Serum Bridging Molecules that Mediate Human Endothelial Cell Invasion by Candida species

This paper identifies serum proteins that mediate endothelial cell invasion by non-C. albicans Candida species through bridging molecule-mediated endocytosis.

The globular C1q receptor is required for epidermal growth factor receptor signaling during Candida albicans infection

This study identifies proteins interacting with EGFR during C. albicans infection and shows that gC1qR is essential for EGFR signaling and immune responses.

In vivo complex haploinsufficiency-based genetic analysis identifies a transcription factor circuit regulating Candida albicans oropharyngeal infection and epithelial cell endocytosis

The paper identifies a transcription factor circuit regulating C. albicans oropharyngeal infection and epithelial cell endocytosis through genetic interaction analysis in a mouse model.

Identification of Candida glabrata Transcriptional Regulators that Govern Stress Resistance and Virulence

This study identifies histone modification genes critical for Candida glabrata's resistance to host defense peptides and caspofungin, and their role in virulence.

Determining Aspergillus fumigatus transcription factor expression and function during invasion of the mammalian lung

The paper identifies two transcription factors, RlmA and Ace1, critical for Aspergillus fumigatus virulence by analyzing gene expression during lung infection in mice.

Activation of oral epithelial EphA2-EFGR signaling by Candida albicans virulence factors

This study investigates how Candida albicans virulence factors Als3 and Ece1/Candidalysin interact with host receptors EphA2 and EGFR to induce inflammation during oropharyngeal candidiasis.

Epha2, An Epithelial Cell Pattern Recognition Receptor For Fungal β-Glucans

This study identifies EphA2 as a pattern recognition receptor that detects fungal β-glucans on Candida albicans, triggering an inflammatory response in oral epithelial cells.