E. Yirmiya

Phages reconstitute NAD+ to counter bacterial immunity

This study identifies two phage pathways, NARP1 and NARP2, that reconstitute NAD+ from its degradation products to counter bacterial immunity.

TIR domains produce histidine-ADPR conjugates as immune signaling molecules in bacteria

The paper identifies His-ADPR as a novel TIR-derived immune signaling molecule in bacteria, showing its role in phage defense and structural basis for recognition.

CARD-like domains mediate anti-phage defense in bacterial gasdermin systems

This study identifies CARD-like domains in bacterial defense systems that activate gasdermin-mediated cell death against phage infection.

Structural basis of Gabija anti-phage defense and viral immune evasion

This study reveals the structural basis of the Gabija anti-phage defense complex and identifies a viral immune evasion mechanism through phage-encoded Gad1.

A conserved family of immune effectors cleaves cellular ATP upon viral infection

This study identifies a conserved family of immune effectors that degrade ATP and dATP during viral infection, halting phage propagation and suggesting a conserved innate immune strategy across life.

Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

The paper identifies Tad1 proteins as inhibitors of TIR-domain signaling in bacterial antiphage systems, revealing gcADPR as the immune signaling molecule and its sequestration by Tad1.

Bacterial gasdermins reveal an ancient mechanism of cell death

This study identifies bacterial gasdermin homologs that execute prokaryotic cell death via caspase-like protease activation, revealing an ancient mechanism of regulated cell death shared with animals.

Antiviral defense via nucleotide depletion in bacteria

This study identifies bacterial proteins that deplete specific deoxynucleotides to inhibit phage replication, mirroring the human SAMHD1 antiviral mechanism.