Author

Y.-F. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Plant Biology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:plant (other)· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

B.-J. Chiang· 2 shared C.-H. Wu· 2 shared C.-Y. Huang· 2 shared K.-Y. Lin· 2 shared L.-T. Huang· 2 shared A. Mohan· 1 shared A. P. West· 1 shared A. Toghani· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersPlant Biology

B.-J. Chiang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Development of a tightly regulated copper-inducible transient gene expression system in Nicotiana benthamiana incorporating suicide exon and Cre recombinase

B.-J. Chiang, K.-Y. Lin, Y.-F. Chen, C.-Y. Huang, F.-J. Goh, L.-T. Huang, L.-H. Chen, C.-H. Wu

This paper develops a copper-inducible gene expression system in Nicotiana benthamiana to tightly regulate transgene expression and cell death assays.

bioRxiv · Mar 23, 2024 · PreprintPlant Biology

Functional divergence shaped the network architecture of plant immune receptors

C.-Y. Huang, Y.-S. Huang, Y. Sugihara, H.-Y. Wang, L.-T. Huang, J. C. Lopez-Agudelo, Y.-F. Chen, K.-Y. Lin, B.-J. Chiang, A. Toghani, J. Kourelis, L. Derevnina, C.-H. Wu

The paper shows how functional divergence in NRC3 variants shapes the genetic architecture of the NLR network in solanaceous plants, leading to subfunctionalization and increased immune system complexity.

bioRxiv · Dec 12, 2023 · PreprintPlant Biology

The anti-platelet drug cilostazol enhances interrenal steroidogenesis and exerts a scant effect on innate immune responses in zebrafish

W.-C. Chang, M.-J. Chen, Y.-F. Chen, C.-W. Chou, Y.-J. Chuang, Y.-W. Liu

This study shows cilostazol enhances steroidogenesis in zebrafish interrenal tissue but has minimal impact on innate immune responses during tissue injury and repair.

bioRxiv · Dec 30, 2022 · PreprintPharmacology & Toxicology

AGO2a but not AGO2b mediates antiviral defense against the infection of wildtype Cucumber mosaic virus in tomato

L.-L. Zhao, Y.-F. Chen, X.-M. Xiao, H.-Y. Gao, J.-M. Cao, Z.-K. Zhang, Z. Guo

The paper investigates the role of AGO2a and AGO2b in antiviral RNAi in tomato, finding AGO2a, but not AGO2b, inhibits wildtype Cucumber mosaic virus propagation.

bioRxiv · Nov 23, 2022Immunology

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Y. Lei, J. J. Vanportfliet, Y.-F. Chen, J. D. Bryant, Y. Li, D. Fails, S. Torres Odio, K. B. Ragan, J. Deng, A. Mohan, B. Wang, O. Brahms, S. Yates, M. Spencer, C. W. Tong, , A. P. West

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

bioRxiv · May 30, 2022Immunology

Reduced PABPN1 levels causes cytoskeleton disorganization and aberrant differentiation

V. Raz, E. van der Wal, C. Domagoj, C. S. Olie, L. Maton, J. C. de Greef, I.-H. Lin, Y.-F. Chen, E. Kareem, J. M. Penninger, B. Kessler

This study shows that reduced PABPN1 levels disrupt cytoskeletal organization and impair muscle differentiation, with actin overexpression improving these defects.

bioRxiv · Jan 15, 2020 · PreprintCell Biology