Author

M.-J. Gubbels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Cell Biology· 3

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Research Focus:cell type annotation· 8 Approach:experimental assay· 8 Organism:human· 6 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 4 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

K. Engelberg· 5 shared I. Coppens· 4 shared B. I. Coleman· 3 shared C. D. Keroack· 3 shared K. Zarringhalam· 3 shared S. Saha· 3 shared Y. Rezvani· 3 shared A. A. Drozda· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersMicrobiology

K. Engelberg

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Author profile →

11 papers

Recent·Most cited

Single cell expression and chromatin access of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential pivotal controller of a ribosome regulon

J. Lou, Y. Rezvani, A. Arriojas, D. Degras, C. D. Keroack, M. Duraisingh, K. Zarringhalam, M.-J. Gubbels

The paper maps transcriptional and chromatin changes during the Toxoplasma gondii lytic cycle, identifying AP2XII-8 as a key regulator of a ribosome regulon.

bioRxiv · Oct 6, 2023 · PreprintMicrobiology

Toxoplasma gondii-s basal complex: the other apicomplexan business end is multifunctional

M.-J. Gubbels, D. J. Ferguson, S. Saha, J. D. Romano, S. Chavan, V. A. Primo, C. Michaud, I. Coppens, K. Engelberg

This paper reviews and expands understanding of the basal complex in Toxoplasma gondii, highlighting its multifunctional roles in cell division, import, and motility.

bioRxiv · Feb 23, 2022Cell Biology

Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases

B. Elsworth, C. D. Keroack, Y. Rezvani, J. A. Tennessen, S. A. Sack, A. Paul, C. K. Moreira, M.-J. Gubbels, K. Zarringhalam, M. T. Duraisingh

This study identifies essential kinases and proteases involved in Babesia divergens egress and invasion, suggesting potential drug targets.

bioRxiv · Feb 17, 2022 · PreprintMicrobiology

A more complex basal complex: novel components mapped to the Toxoplasma gondii cytokinesis machinery portray an expanded hierarchy of its assembly and function

K. Engelberg, T. Bechtel, C. Michaud, E. Weerapana, M.-J. Gubbels

This study maps the Toxoplasma gondii basal complex proteome and identifies new components, revealing a dynamic, hierarchical assembly process critical for cytokinesis.

bioRxiv · Oct 14, 2021 · PreprintMicrobiology

The extracellular milieu of Toxoplasma-s lytic cycle drives lab-adaptation and promotes changes in lipid metabolism primarily driven by transcriptional reprogramming

V. A. Primo, Y. Rezvani, A. Farrell, A. Vajdi Hoojghan, G. T. Marth, K. Zarringhalam, M.-J. Gubbels

This study uses evolve and resequence to identify genetic changes in Toxoplasma gondii during lab-adaptation, revealing transcriptional reprogramming and lipid metabolism shifts.

bioRxiv · Mar 9, 2021 · PreprintMicrobiology

Fussing about fission: defining variety among mainstream and exotic apicomplexan cell division modes

M.-J. Gubbels, C. D. Keroack, S. Dangoudoubiyam, H. L. Worliczek, A. S. Paul, C. Bauwens, B. Elsworth, K. Engelberg, D. K. Howe, I. Coppens, M. T. Duraisingh

This paper defines and classifies different cell division modes in Apicomplexa parasites, highlighting variations in budding site, offspring number, and karyokinesis timing across species and life stages.

Frontiers in Cellular and Infection Microbiology · Jun 5, 2020Peer-reviewedMicrobiology

Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis

D. N. Tagoe, A. Ribeiro E Silva, A. A. Drozda, I. Coppens, B. I. Coleman, M.-J. Gubbels

This study identifies FER1 as a key mediator of microneme trafficking and exocytosis in Toxoplasma gondii, showing its dynamic role in organelle transport and secretion.

bioRxiv · Apr 27, 2020 · PreprintCell Biology

The apical annuli of Toxoplasma gondii are composed of coiled-coil and signaling proteins embedded in the IMC sutures

K. Engelberg, C.-T. Chen, T. Bechtel, V. Sanchez Guzman, A. A. Drozda, S. Chavan, E. Weerapana, M.-J. Gubbels

This study identifies and characterizes apical annuli proteins in Toxoplasma gondii using BioID and SR-SIM, revealing their structural and functional roles in parasite replication and signaling.

Cellular Microbiology · Sep 10, 2019Peer-reviewedCell Biology

TgCep250 is dynamically processed through the division cycle and essential for structural integrity of the Toxoplasma centrosome

C.-T. Chen, M.-J. Gubbels

This study identifies TgCep250 as a protein essential for maintaining the structural integrity of the Toxoplasma centrosome during the cell cycle, ensuring proper nuclear partitioning.

bioRxiv · Oct 3, 2018Microbiology

A member of the ferlin calcium sensor family is essential for Toxoplasma gondii rhoptry secretion

B. I. Coleman, S. Saha, S. Sato, K. Engelberg, D. J. P. Ferguson, I. Coppens, M. B. Lodoen, M.-J. Gubbels

This study identifies TgFER2, a Ca2+ sensor essential for rhoptry secretion in Toxoplasma gondii, which is required for host cell invasion.

bioRxiv · Apr 18, 2018Microbiology

Two phosphoglucomutase paralogs regulate triggered secretion of the Toxoplasma micronemes

S. Saha, B. I. Coleman, T. Sansom, R. Dubey, I. J. Blader, M.-J. Gubbels

The paper shows that two phosphoglucomutase paralogs in Toxoplasma gondii regulate calcium-triggered microneme secretion but are not essential for completing the lytic cycle.

bioRxiv · Jun 30, 2017Microbiology