Author

D. J. P. Ferguson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 8 Research Focus:cell signaling & trafficking· 6 Organism:plant (other)· 4 Assay:proteomics· 4 Assay:electronic health records· 3 Approach:microscopy & imaging analysis· 3 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

D. Brady· 6 shared M. Zeeshan· 6 shared R. Tewari· 6 shared A. A. Holder· 5 shared K. G. Le Roch· 4 shared S. Abel· 4 shared S. Vaughan· 4 shared C. A. Moores· 3 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersCell Biology

D. Brady

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

LARP1 regulates metabolism and mTORC1 activity in cancer

J. Chettle, Z. Dedeic, R. Fischer, I. Vendrell, L. Campo, A. Easton, M. Browne, J. Morris, H. Schwenzer, P. Lascaux, R. Gijsbers, E. Pires, D. J. Royston, D. J. P. Ferguson, A. Coosemans, , S. P. Blagden

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

bioRxiv · Sep 4, 2022 · PreprintCancer Biology

Cellular electron tomography of the apical complex in the apicomplexan parasite Eimeria tenella shows a highly organised gateway for regulated secretion.

A. Burrell, V. Marugan-Hernandez, F. Moreira-Leite, D. J. P. Ferguson, F. M. Tomley, S. Vaughan

This study uses electron tomography to reveal the 3D structure of the apical complex in Eimeria tenella, showing organized trafficking and secretion mechanisms.

bioRxiv · Jun 17, 2021Microbiology

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

M. Zeeshan, R. Rashpa, D. J. P. Ferguson, S. Abel, Z. Chahine, D. Brady, s. vaughan, C. A. Moores, K. G. Le Roch, M. Brochet, A. A. Holder, R. Tewari

The paper identifies key kinesins involved in the malaria parasite life cycle in mammalian and mosquito hosts, showing kinesin-13 is essential for growth in mammals while others are critical for mosquito transmission.

bioRxiv · May 26, 2021Cell Biology

Protein Phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages

M. Zeeshan, R. Pandey, A. K. SUBUDHI, D. J. P. Ferguson, G. Kaur, R. Rashpa, R. Nugmanova, D. Brady, A. Bottrill, S. Vaughan, M. Brochet, M. Bollen, A. Pain, A. A. Holder, D. S. Guttery, R. Tewari

The paper investigates the role of Protein Phosphatase 1 (PP1) in atypical mitotic and meiotic divisions during Plasmodium sexual stages, suggesting PP1 inhibitors could block parasite transmission.

bioRxiv · Jan 15, 2021Cell Biology

Conservation of the Toxoplasma conoid complex proteome reveals a cryptic conoid in Plasmodium that differentiates between blood- and vector-stage zoites

L. Koreny, M. Zeeshan, K. Barylyuk, E. C. Tromer, J. J. E. van Hooff, D. Brady, H. Ke, S. Chelaghma, D. J. P. Ferguson, L. Eme, R. Tewari, R. F. Waller

The paper uses spatial proteomics and microscopy to show the conoid is conserved across apicomplexans, including Plasmodium, with structural differences between blood and vector stages.

bioRxiv · Jun 26, 2020Cell Biology

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation

M. Zeeshan, R. Pandey, D. J. P. Ferguson, E. C. Tromer, R. Markus, S. Abel, D. Brady, E. Daniel, R. R. Stanway, A. R. Bottrill, K. G. Le Roch, A. A. Holder, R. F. Waller, D. S. Guttery, R. Tewari

The paper studies the dynamics of the NDC80 complex in Plasmodium berghei to reveal unique chromosome segregation mechanisms during parasite proliferation.

bioRxiv · May 12, 2020Cell Biology

Vital role for Plasmodium berghei Kinesin8B in axoneme assembly during male gamete formation and mosquito transmission

D. Depoix, S. R. Marques, D. J. P. Ferguson, S. Chaouch, T. Duguet, R. E. Sinden, P. Grellier, L. Kohl

This study identifies PbKIN8B as essential for axoneme assembly in Plasmodium berghei male gametes, disrupting mosquito transmission when knocked out.

bioRxiv · Jul 31, 2019Cell Biology

Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission

M. Zeeshan, D. J. P. Ferguson, S. Abel, A. Burrrell, E. Rea, D. Brady, E. Daniel, M. Delves, S. Vaughan, A. A. Holder, K. G. Le Roch, C. A. Moores, R. Tewari

This study identifies kinesin-8B's role in malaria parasite flagellum formation and transmission by analyzing its localization and function during gamete development.

bioRxiv · Jul 2, 2019Cell Biology

Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

M. Zeeshan, F. Shilliday, T. Liu, S. Abel, T. Mourier, D. J. P. Ferguson, E. Rea, R. R. Stanway, M. Roques, D. Williams, E. Daniel, D. Brady, A. J. Roberts, A. A. Holder, A. Pain, , R. Tewari

This study identifies Plasmodium Kinesin-8X as essential for endomitotic division during oocyst development and parasite transmission.

bioRxiv · Jun 29, 2019Cell Biology

A member of the ferlin calcium sensor family is essential for Toxoplasma gondii rhoptry secretion

B. I. Coleman, S. Saha, S. Sato, K. Engelberg, D. J. P. Ferguson, I. Coppens, M. B. Lodoen, M.-J. Gubbels

This study identifies TgFER2, a Ca2+ sensor essential for rhoptry secretion in Toxoplasma gondii, which is required for host cell invasion.

bioRxiv · Apr 18, 2018Microbiology