Author

M.-Y. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:organoid / primary culture· 6 Organism:human· 5 Research Focus:drug response / drug discovery· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

P. Acharya· 6 shared S. Shrestha· 6 shared P. Joshi· 5 shared S.-Y. Kang· 5 shared V. K. R. Lekkala· 4 shared J. Liu· 3 shared Y. Yang· 3 shared M. G. Vanga· 2 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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6 shared papersBioengineering

P. Acharya

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Author profile →

6 papers

Recent·Most cited

Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assays

S. Shrestha, P. Acharya, S.-Y. Kang, M. G. Vanga, V. K. R. Lekkala, J. Liu, Y. Yang, P. Joshi, M.-Y. Lee

This paper develops a bioprinted liver organoid system for high-throughput hepatotoxicity assays, showing improved maturity, reproducibility, and regenerative capacity after drug exposure.

bioRxiv · Mar 25, 2024 · PreprintBioengineering

Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicity

P. Acharya, S. Shrestha, P. Joshi, N. Y. Choi, V. K. R. Lekkala, S.-Y. Kang, G. Ni, M.-Y. Lee

This study evaluates developmental neurotoxicity using dynamic cerebral organoid cultures in a pillar/perfusion plate, showing methylmercury induces changes in morphology and gene expression under dynamic conditions but not static ones.

bioRxiv · Mar 11, 2024Bioengineering

Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting

S. Shrestha, V. K. R. Lekkala, P. Acharya, S.-Y. Kang, M. G. Vanga, M.-Y. Lee

This paper develops a microarray 3D bioprinting method to generate human liver organoids on a pillar plate, enabling high-throughput, reproducible hepatotoxicity assays with improved efficiency and function.

bioRxiv · Mar 11, 2024Bioengineering

Uniform cerebral organoid culture on a pillar plate by simple and reproducible spheroid transfer from an ultralow attachment well plate

P. Acharya, P. Joshi, S. Shrestha, N. Y. Choi, S. Jeong, M.-Y. Lee

This paper introduces a method to generate reproducible cerebral organoids from iPSCs using a pillar plate platform, improving throughput and reducing variability compared to traditional methods.

bioRxiv · Apr 21, 2023Bioengineering

A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

S.-Y. Kang, M. Kimura, S. Shrestha, P. Lewis, S. Lee, Y. Cai, P. Joshi, P. Acharya, J. Liu, Y. Yang, J. G. Sanchez, S. Ayyagari, E. Alsberg, J. Wells, T. Takebe, M.-Y. Lee

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

bioRxiv · Mar 11, 2023Bioengineering

A pillar/perfusion plate enhances cell growth, reproducibility, throughput, and user friendliness in dynamic 3D cell culture

V. K. R. Lekkala, S.-Y. Kang, J. Liu, S. Shrestha, P. Acharya, P. Joshi, M. Zolfaghar, M. Lee, P. Jamdagneya, S. Pagnis, A. Kundi, S. Kabbur, U. T. Kim, Y. Yang, M.-Y. Lee

The paper introduces a pillar/perfusion plate for dynamic 3D cell culture, improving growth, reproducibility, throughput, and user friendliness compared to static methods.

bioRxiv · Feb 16, 2023Bioengineering