Author

Rupam Tripura

Mahidol UniversityORCID 0000-0002-3281-9702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:plant (other)· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Dysoley Lek· 3 shared Mehul DhordaiD· 3 shared Ann N. Reyes· 2 shared Ashley M. VaughaniD· 2 shared Biley A. Abatiyow· 2 shared Douglas A. ShoueiD· 2 shared François Henry NosteniD· 2 shared Ian H. CheesemaniD· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Dysoley Lek

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Using a P. falciparum genetic cross to dissect the relative contributions of pfcrt and plasmepsin II/III to piperaquine response-related traits

John Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann N. Reyes, Rupam Tripura, , Michael T. Ferdig

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

bioRxiv · Jun 6, 2023 · PreprintGenomics

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

Katelyn M. Vendrely, Xue Li, Sudhir Kumar, Elizabeth Delgado, Lisa A. Checkley, Douglas A. Shoue, Ann N. Reyes, Biley A. Abatiyow, Meseret T. Haile, Rupam Tripura, Thomas Julian Peto, Dysoley Lek, Katrina A. Button-Simons, Stefan H. I. Kappe, Mehul Dhorda, , Tim Anderson

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

iScience · Mar 16, 2022Peer-reviewedGenomics

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.

Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Henry Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, Frank M. Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, , Zbynek Bozdech

The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.

bioRxiv · May 17, 2021 · PreprintSystems Biology