CAR Treg synergy with anti-CD154 mediates infectious tolerance to dictate heart transplant outcomes.
Samarth S. Durgam, Isaac Rosado‐Sánchez, D. Yin, Madeleine Speck, Majid Mojibian, Ismail Sayin, Grace E. Hynes, Maria‐Luisa Alegre, Megan K. Levings, Anita S. Chong
This study shows that A2-specific CAR Tregs synergize with anti-CD154 to promote graft survival in haplo-mismatched heart transplants by inhibiting donor-specific immune responses.
JCI Insight · Apr 7, 2025Peer-reviewedImmunology