Majid Mojibian

The paper shows beta cells transfer mitochondria to islet macrophages, enhancing their protein synthesis and altering gene expression, suggesting a new communication mechanism in islet homeostasis.

This study shows regenerative macrophages enhance beta cell survival, function, and proliferation in vitro through contact-independent mechanisms and promote a regenerative macrophage phenotype.

A2-CAR Tregs reduce BDC2.5 T cell engraftment, proliferation, and cytokine production, protecting mice from diabetes and inducing systemic tolerance.

This study engineers CAR Tregs to secrete IL-10 via PDCD1-driven regulation, enhancing their suppressive function in vitro and in vivo.

This study shows that A2-specific CAR Tregs synergize with anti-CD154 to promote graft survival in haplo-mismatched heart transplants by inhibiting donor-specific immune responses.