Extracellular vesicles facilitate the horizontal transfer of drug resistance and stem-like properties between ovarian tumor cells
Venkatesh Pooladanda, Rui Fang Xu, Dominique T. Zarrella, Yusuke Matoba, Chisa Shimada, Shaan Kumar, Eugene Kim, Paula J DiBenedetto, Xingping Qin, Kristopher A. Sarosiek, Madelyn Krueger, Narela Magrassi, Mansoor M. Amiji, Maryam Azimi Mohammadabadi, Ursula Winter, , Bo R. Rueda
This study shows that extracellular vesicles from ovarian cancer stem cells or drug-resistant cells transfer stem-like properties and drug resistance to sensitive cells via EZH2 signaling.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology