Author

Shaan Kumar

Harvard UniversityORCID 0000-0002-9786-1063Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:organoid / primary culture· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bo R. RuedaiD· 2 shared Eugene KimiD· 2 shared Venkatesh PooladandaiD· 2 shared Abby E. Smith· 1 shared Adriaan F. Hubertus de Groot· 1 shared Alexander Daniel CarliniD· 1 shared Anthony P. PossematoiD· 1 shared Benedikt R. Dürr· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Bo R. RuedaORCID

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2 papers

Recent·Most cited

Extracellular vesicles facilitate the horizontal transfer of drug resistance and stem-like properties between ovarian tumor cells

Venkatesh Pooladanda, Rui Fang Xu, Dominique T. Zarrella, Yusuke Matoba, Chisa Shimada, Shaan Kumar, Eugene Kim, Paula J DiBenedetto, Xingping Qin, Kristopher A. Sarosiek, Madelyn Krueger, Narela Magrassi, Mansoor M. Amiji, Maryam Azimi Mohammadabadi, Ursula Winter, , Bo R. Rueda

This study shows that extracellular vesicles from ovarian cancer stem cells or drug-resistant cells transfer stem-like properties and drug resistance to sensitive cells via EZH2 signaling.

bioRxiv · Jan 23, 2026 · PreprintCancer Biology

Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway

Junbing Zhang, Claire M. Simpson, Jacqueline Berner, Harrison Byron Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss‐Sadan, Anthony P. Possemato, Stefan Andrew Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander Daniel Carlin, , Liron Bar‐Peled

The paper identifies a nucleus-to-mitochondria ROS sensing pathway involving CHK1 and SSBP1 that mediates resistance to platinum-based chemotherapies in ovarian cancers.

bioRxiv · Mar 11, 2023 · PreprintMolecular Biology