Differential Regulation of Large-scale Chromosome Conformations in Osteoblasts and Osteosarcoma
Madhoolika Bisht, Yu-Chieh Chung, Siou-Luan He, Sydney Willey, Benjamin D. Sunkel, Meng Wang, Benjamin Z. Stanton, Li‐Chun Tu
The paper uses CRISPR-Sirius to visualize differences in large-scale chromosome conformations between osteoblasts and osteosarcoma cells, revealing regulatory mechanisms involving H3K27me3 and CTCF/cohesin.
Genome biology · Sep 26, 2025Peer-reviewedCell Biology