Siou-Luan He

CRISPR-FOIL engineers chromatin loops and compaction in live human cells using CRISPR to visualize and manipulate chromatin structure, showing its potential for gene regulation and disease therapy.

The paper investigates how MAPK signaling affects DCP1 localization between P-bodies and stress granules in plant cells, showing phosphorylation shifts DCP1 from P-bodies to stress granules.

The paper uses CRISPR-Sirius to visualize differences in large-scale chromosome conformations between osteoblasts and osteosarcoma cells, revealing regulatory mechanisms involving H3K27me3 and CTCF/cohesin.

This study identifies phosphorylation and ubiquitination as key regulators of TZF1 stress granule assembly in Arabidopsis.