Sydney Willey

The paper shows that neurons prefer cap-independent RAN translation from specific repeats, linked to altered start codon stringency and eIF1 redistribution.

CRISPR-FOIL engineers chromatin loops and compaction in live human cells using CRISPR to visualize and manipulate chromatin structure, showing its potential for gene regulation and disease therapy.

The paper uses CRISPR-Sirius to visualize differences in large-scale chromosome conformations between osteoblasts and osteosarcoma cells, revealing regulatory mechanisms involving H3K27me3 and CTCF/cohesin.

This study shows that AAGGG repeat expansions cause synaptic defects in CANVAS neurons independently of RFC1, with phenotypes corrected by repeat deletion.

This study identifies TDP43 autoregulation as a source of shortened isoforms, showing they are regulated by NMD and post-translational degradation, and their dysregulation leads to neurodegeneration.