Interplay of NuA4/TIP60 and PRC2 Complex Activities in Fusion Driven Endometrial Stromal Sarcoma
Deepthi Sudarshan, Charles Joly-Beauparlant, Stéphanie Bianco, Catherine Lachance, Maelys Le Goff, Nader Alerasool, Elliot Gregoire, Lara Herrmann, Christophe Tav, Jean‐Philippe Lambert, Marcus Q. Bernardini, Arnaud Droit, Mikko Taipale, Jacques Côté
This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.
bioRxiv · Sep 11, 2026 · PreprintCancer Biology