Nader Alerasool

Interplay of NuA4/TIP60 and PRC2 Complex Activities in Fusion Driven Endometrial Stromal Sarcoma

This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.

X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language Models

X-Cell predicts causal perturbation responses across diverse cellular contexts using a diffusion language model trained on a large CRISPRi Perturb-seq dataset.

Proteome-scale induced proximity screens reveal highly potent protein degraders and stabilizers

The paper identifies potent protein degraders and stabilizers using proteome-scale induced proximity screens and shows they outperform existing E3 ligases.

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

This paper characterizes the ZMYND11-MBTD1 fusion protein's role in oncogenesis by mislocalizing the NuA4/TIP60 complex to gene bodies, altering transcription and splicing, particularly of the MYC oncogene.

MRG proteins are shared by multiple protein complexes with distinct functions

The paper identifies and characterizes multiple protein complexes associated with MRG15 and MRGX, revealing their roles in chromatin modification and transcription regulation.

Identification and functional characterization of transcriptional activators in human cells

The paper identifies and functionally characterizes transcriptional activators in human cells, revealing novel activators involved in tumor fusion events.

Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.