Engineered spermidine-secreting Saccharomyces boulardii ameliorate colitis and colon cancer in mice
Mahdi Mohaqiq, Roger Palou, Ruizhen Li, Guijun Zhang, Het T. Vaishnav, Florance Parweez, Terence N. Moyana, Damian M. Carragher, D. William Cameron, Tim Ramsay, Almer M. van der Sloot, Sanjay K. Murthy, Brian K. Coombes, Mike Tyers, X. Johné Liu
This study engineers S. boulardii to secrete spermidine, showing improved efficacy in reducing colitis and colon cancer in mice compared to wild-type strains.
Scientific Reports · Aug 30, 2025Peer-reviewedCancer Biology