Author

Brian K. Coombes

Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0000-0001-9883-1010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Aline Fiebig‐ComyniD· 4 shared Megan T. ZangaraiD· 3 shared Almer M. van der SlootiD· 2 shared Gerard D. WrightiD· 2 shared Michael A. CookiD· 2 shared Michael Gordon SuretteiD· 2 shared Mike TyersiD· 2 shared Roger PalouiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

Aline Fiebig‐ComynORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Phage intervention improves colitis and response to corticosteroids by attenuating virulence of Crohn's disease-associated bacteria

Kyle J. Jackson, Heather Jean Galipeau, Amber Hann, Marco Constante, Megan T. Zangara, Michael Bording‐Jorgensen, Alexandra Fuentes, Heidi Ho, Jessica Wang, Chiko Shimbori, Paul Moayyedi, Michael Gordon Surette, Přemysl Berčík, Brian K. Coombes, Zeinab Hosseinidoust, Elena Francisca Verdu

Phage HER259 reduces colitis severity caused by AIEC NRG857c and enhances budesonide efficacy in mice.

Science Translational Medicine · Jul 8, 2026Peer-reviewedMicrobiology

Peyer's patches are a niche for antibiotic-driven expansion of Crohn's disease-associated adherent-invasive Escherichia coli

Katarina R Iacobucci, Dominique Tertigas, Aline Fiebig‐Comyn, Megan T. Zangara, Michael Gordon Surette, Brian K. Coombes

This study shows antibiotic treatment increases AIEC burden in Peyers patches, leading to focal inflammation, and identifies specific AIEC traits required for niche colonization and immunopathology.

bioRxiv · May 21, 2026 · PreprintMicrobiology

Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition

Xuefei Chen, H. Diessel Duan, Michael J. Hoy, Kalinka K. Koteva, Michaela Spitzer, Allison K. Guitor, Emily Puumala, Aline Fiebig‐Comyn, Guanggan Hu, Bonnie Yiu, Sommer Chou, Zhuyun Bian, Yeseul Choi, Amelia Bing Ya Guo, Wenliang Wang, , Gerard D. Wright

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

Cell · Dec 31, 2025Peer-reviewedBiochemistry

The Salmonella phage shock protein system is required for defense against host antimicrobial peptides

Marie-Ange Massicotte, Aline Fiebig‐Comyn, Andrei Bogza, Brian K. Coombes

This study identifies the phage shock protein (Psp) system as critical for Salmonella survival within macrophages by mediating resistance to host antimicrobial peptides.

PLoS Pathogens · Sep 9, 2025Peer-reviewedMicrobiology

Engineered spermidine-secreting Saccharomyces boulardii ameliorate colitis and colon cancer in mice

Mahdi Mohaqiq, Roger Palou, Ruizhen Li, Guijun Zhang, Het T. Vaishnav, Florance Parweez, Terence N. Moyana, Damian M. Carragher, D. William Cameron, Tim Ramsay, Almer M. van der Sloot, Sanjay K. Murthy, Brian K. Coombes, Mike Tyers, X. Johné Liu

This study engineers S. boulardii to secrete spermidine, showing improved efficacy in reducing colitis and colon cancer in mice compared to wild-type strains.

Scientific Reports · Aug 30, 2025Peer-reviewedCancer Biology

A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation

Roger Palou, Almer M. van der Sloot, Aline Fiebig‐Comyn, Megan T. Zangara, Naseer Sangwan, María Sánchez‐Osuna, Bushra Ilyas, Haley L. Zubyk, Michael A. Cook, Gerard D. Wright, Brian K. Coombes, Mike Tyers

This paper develops a Saccharomyces boulardii platform for producing and delivering therapeutic nanobodies to treat gastrointestinal inflammation in mice.

bioRxiv · May 15, 2025 · PreprintSynthetic Biology