Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy
Adam Blaisdell, Stefanie Bachl, Luis R Sandoval, Carter Ching, Christopher Bowman, Nupura Kale, Manu Prabandham, Morgan E. Diolaiti, Claire C. Havig, Rommel Advincula, Nika Lenci, Zhongmei Li, Emily Yamashita, Charlotte H. Wang, Shimin Zhang, , Averil I. Ma
This study uses base-editing to inactivate a missense mutation in A20ZF7, enhancing CAR-T cell efficacy by reducing exhaustion and improving anti-tumor responses.
bioRxiv · Oct 5, 2025 · PreprintImmunology