Author

Shimin Zhang

Gladstone InstitutesORCID 0000-0001-6899-4353Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1 Approach:large language model· 1

Frequent Co-Authors

Alexander MarsoniD· 2 shared Charlotte H. WangiD· 2 shared Julia C. CarnevaleiD· 2 shared Justin EyquemiD· 2 shared Nupura KaleiD· 2 shared Adam BlaisdelliD· 1 shared Alan AshworthiD· 1 shared Averil I. MaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Alexander MarsonORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 5, 2025

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

Adam Blaisdell, Stefanie Bachl, Luis R Sandoval…·Averil I. Ma

This study uses base-editing to inactivate a missense mutation in A20ZF7, enhancing CAR-T cell efficacy by reducing exhaustion and improving anti-tumor responses.

DOI 10.1101/2025.10.05.680562

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 23, 2025

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors

Qi Liu, Peixin Amy Chen, Esha Urs…·Julia C. Carnevale

This paper performs in vivo CRISPR screens in human T cells to identify genetic modifiers of T cell function in solid tumors, finding P2RY8-G13 and GNAS as key regulators.

6 citations

humangenetic perturbation / CRISPR

𝕏 PostBluesky