Identification of AB8939, a novel synthetic microtubule destabilizer and ALDH inhibitor that overcomes multidrug resistance in tumor cells as a drug candidate for the treatment of refractory acute myeloid leukemia
Martine Humbert, Sébastien Letard, Armelle Goubard, Camille Montersino, Stéphane Audebert, Émilie Baudelet, Bérengère Hajem, Manuel L Neves, Samila Siavioshian, Paloma F. Varela, Benoı̂t Gigant, E. Rebuffet, Pascal Verdier‐Pinard, Rémy Castellano, Yves Collette, , Patrice C. Dubreuil
This paper identifies AB8939, a novel drug that targets microtubules and ALDH enzymes, showing efficacy against drug-resistant AML cells and models.
bioRxiv · Dec 12, 2025 · PreprintCell Biology