Paloma F. Varela

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

This paper identifies AB8939, a novel drug that targets microtubules and ALDH enzymes, showing efficacy against drug-resistant AML cells and models.

The paper reveals that Rap1 inhibits Ku's NHEJ function at telomeres by obstructing Ku's inward translocation, preventing promiscuous repair.