G protein-Coupled Receptor Associated Sorting ProteinGASP1 mediated trafficking of the Glucagon Like Peptide-1Receptor contributes to the development of tolerance toincretin drugs
Anirudh Gaur, Caroline M. Keeshen, Madeline King, Noah Dirks, Marcus F. Flisher, Bethany P. Cummings, Mark O. Huising, Jennifer L. Whistler
This study shows that GASP1-mediated GLP-1R trafficking contributes to tolerance to incretin drugs, suggesting a strategy to prevent tolerance by biasing drug engagement toward G protein signaling.
bioRxiv · Aug 9, 2024 · PreprintCell Biology