D3 dopamine receptors implicate a striatal neuronal subtype in the aversive effects of the antipsychotic drug quetiapine
Elinor Lewis, Jessie Muir, Ying C. Li, Madeline King, Kaden P. Adams, Julianna Glienke, Sarah Warren Gooding, Kevin J. Bender, Christina K. Kim, Jennifer Lynne Whistler
This study identifies D3R-expressing neurons in the NAc as mediators of quetiapine's aversive effects, showing that chronic treatment reduces this aversion.
bioRxiv · Apr 15, 2025 · PreprintNeuroscience