LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung Cancer
Kunal M. Shah, Paul T. Kennedy, James R. Black, Kevin Litchfield, Krupa Thakkar, Maria F. Contreras-Gerenas, Kirsten Brooksbank, Oliver Yuan, Paul Grevitt, Sarah Charrot, JEFF K. DAVIES, Lekh N. Dahal, Dimitris Lagos, Nicholas McGranahan, Tyson V. Sharp
This study shows that LIMD1 loss in lung cancer increases PD-L1 expression, promoting immune evasion and enhancing response to immune checkpoint inhibitors.
bioRxiv · Feb 6, 2025 · PreprintCancer Biology