Author

Kirsten Brooksbank

Queen Mary University of LondonORCID 0000-0001-6129-2113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Tyson V. SharpiD· 2 shared Amy Gibson· 1 shared Amy Kate Hall· 1 shared Charlotte Smith· 1 shared Dimitris LagosiD· 1 shared Eleni ManiatiiD· 1 shared James R. BlackiD· 1 shared JEFF K. DAVIESiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Tyson V. SharpORCID

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2 papers

Recent·Most cited

Cancer BiologyNeoplasiaPeer-reviewedJul 15, 2025

The DNA Mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression

Kirsten Brooksbank, Charlotte Smith, Eleni Maniati…·Sarah A. Martin

The paper shows that MSH6 regulates PD-L1 expression through SETD2 recruitment, and MSH6 KO cells have lower microsatellite instability despite higher mutational burden compared to MLH1 KO cells.

2 citations

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 6, 2025

LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung Cancer

Kunal M. Shah, Paul T. Kennedy, James R. Black…·Tyson V. Sharp

This study shows that LIMD1 loss in lung cancer increases PD-L1 expression, promoting immune evasion and enhancing response to immune checkpoint inhibitors.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky