Sima Lev

p140Cap enhances breast cancer chemosensitivity by limiting an ABCC1-enriched stem-like compartment via β-Catenin inhibition

This study shows p140Cap improves chemotherapy response in breast cancer by reducing stem-like cells and enhancing drug retention through β-Catenin inhibition.

The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival

This study shows that Otub2 modulates pancreatic beta-cell function and survival by inhibiting NFkB signaling and regulating K+ channels involved in insulin secretion.

Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy

The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.

Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states

The paper identifies Arrdc4's role in suppressing pyroptosis in biphenotypic EMT cells, linking its downregulation to increased metastatic potential and poor prognosis in breast cancer.

TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications

This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.