Giovanni Bertalot

Targeting GL-Lect driven endocytosis to suppress cell plasticity in breast cancer

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels

The paper identifies the CRL7FBXW8 complex as an E3 ligase responsible for NUMB hyper-degradation in breast cancer, showing its inhibition rescues transformation phenotypes.

A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

From Flies to Humans: A Conserved Role of CEBPZ, NOC2L, and NOC3L in rRNA Processing and Tumorigenesis.

This study identifies CEBPZ, NOC2L, and NOC3L as conserved regulators of rRNA processing and tumor growth, showing context-dependent expression patterns in cancers.

Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry

This study identifies Numb loss as a driver of aggressive bladder cancer through hyperactivation of the RhoA/ROCK/YAP signaling pathway, proposing a 27-gene signature for clinical stratification.

IRSp53 shapes the plasma membrane and controls polarized transport at the nascent lumen during epithelial morphogenesis

This study identifies IRSp53's role in shaping the plasma membrane and controlling polarized transport during epithelial morphogenesis by regulating apical lumen formation and polarity determinants.