Author

Marianna Hellén

University of Helsinki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alfredo Ramı́reziD· 1 shared Annakaisa HaapasaloiD· 1 shared Christian HaassiD· 1 shared Dorit Hoffman· 1 shared Esa-Mikko Koivumäki· 1 shared Heikki TanilaiD· 1 shared Heli JeskaneniD· 1 shared Henna JänttiiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alfredo Ramı́rezORCID

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1 paper

Recent·Most cited

Protective variant in PLCgamma2 mitigates Alzheimer's disease associated pathology via enhancing beneficial microglia functions

Mari Takalo, Heli Jeskanen, Taisia Rõlova, Inka Kervinen, Marianna Hellén, Sami Heikkinen, Henna Koivisto, Kimmo T. Jokivarsi, Stephan A. Müller, Esa-Mikko Koivumäki, Petra M. Mäkinen, Sini-Pauliina Juopperi, Roosa-Maria Willman, Rosa Sinisalo, Dorit Hoffman, , Mikko Hiltunen

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

bioRxiv · Sep 12, 2024 · PreprintNeuroscience