Developmental Programming of Mitochondrial Function Limits Lifespan in Short-Lived Animals
Beatriz Castejón‐Vega, Ignacio Fernandez-Guerrero, Yizhou Yu, Rachel Zussman, Tetsushi Kataura, Rhoda K.A. Stefanatos, Sarah Allison, Davide D’Andrea, Mario Cordero, Miloš R. Filipović, Miguel Martins, Viktor I. Korolchuk, Alberto Sanz
This study shows that developmental mitochondrial dysfunction limits lifespan in Drosophila, while adult dysfunction accelerates ageing, with metabolic adaptations during development being critical for survival.
bioRxiv · Jun 23, 2023 · PreprintMolecular Biology