Author

Rhoda K.A. Stefanatos

Wellcome Centre for Mitochondrial ResearchORCID 0000-0002-9072-7224Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alberto SanziD· 2 shared Beatriz Castejón‐VegaiD· 2 shared L. Miguel MartinsiD· 2 shared Tetsushi KatauraiD· 2 shared Viktor I. KorolchukiD· 2 shared Yizhou YuiD· 2 shared Alejandro Huerta UribeiD· 1 shared Davide D’Andrea· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMolecular Biology

Alberto SanzORCID

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2 papers

Recent·Most cited

Developmental mitochondrial Complex I activity determines lifespan

Rhoda K.A. Stefanatos, Fiona M. Robertson, Beatriz Castejón‐Vega, Yizhou Yu, Alejandro Huerta Uribe, Kevin Myers, Tetsushi Kataura, Viktor I. Korolchuk, Oliver D.K. Maddocks, L. Miguel Martins, Alberto Sanz

This study shows that developmental mitochondrial complex I dysfunction reduces lifespan and stress resistance, while adult-onset dysfunction increases lifespan and stress resistance.

EMBO Reports · Mar 17, 2025Peer-reviewedMolecular Biology

Developmental Programming of Mitochondrial Function Limits Lifespan in Short-Lived Animals

Beatriz Castejón‐Vega, Ignacio Fernandez-Guerrero, Yizhou Yu, Rachel Zussman, Tetsushi Kataura, Rhoda K.A. Stefanatos, Sarah Allison, Davide D’Andrea, Mario Cordero, Miloš R. Filipović, Miguel Martins, Viktor I. Korolchuk, Alberto Sanz

This study shows that developmental mitochondrial dysfunction limits lifespan in Drosophila, while adult dysfunction accelerates ageing, with metabolic adaptations during development being critical for survival.

bioRxiv · Jun 23, 2023 · PreprintMolecular Biology