Yizhou Yu

The paper identifies integrin and BMP signaling pathways that drive OPC-to-SC differentiation in CNS regeneration using single-cell genomics.

This study shows that developmental mitochondrial complex I dysfunction reduces lifespan and stress resistance, while adult-onset dysfunction increases lifespan and stress resistance.

The paper links amyloid-β forms to sleep duration changes in Alzheimer's disease via NAD+-linked redox metabolism using Drosophila models and human data.

This study shows that developmental mitochondrial dysfunction limits lifespan in Drosophila, while adult dysfunction accelerates ageing, with metabolic adaptations during development being critical for survival.

The paper identifies age-dependent activation of Trem2-targeted immune genes in a mouse AD model, showing early-stage DAM activation rather than late-stage.