Miloš R. Filipović

This study shows that reducing Integrator complex activity in adult C. elegans extends lifespan and healthspan by disrupting RNA processing and mitochondrial function.

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

This study shows that SOX deficiency leads to persulfidation loss and increased H2S release, with thiosulfate accumulation and metabolic rewiring in a mouse model.

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

This study identifies endogenous hydrogen cyanide as a novel gasotransmitter in mammals, showing it regulates mitochondrial function and cell metabolism at optimal levels.

This study shows that developmental mitochondrial dysfunction limits lifespan in Drosophila, while adult dysfunction accelerates ageing, with metabolic adaptations during development being critical for survival.