Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer
Xiaoding Hu, Yun Xiong, Emilly S. Villodre, Huiming Zhang, Juhee Song, Natalie Wall Fowlkes, Savitri Krishnamurthy, Marissa Nichole Rylander, Chandra Bartholomeusz, Debu Tripathy, The MDACC Inflammatory Breast Cancer Team, Wendy A. Woodward, Junjie Chen, Bisrat Godefay Debeb
This study identifies soluble E-cadherin as a driver of brain metastasis in inflammatory breast cancer, showing it promotes tumor survival and metastasis through XIAP-NF-kB activation and reactive astrocytosis.
bioRxiv · Jun 18, 2025 · PreprintCancer Biology